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Journal of Genetics and Genomics 微生物組學(xué)專刊已經(jīng)在線發(fā)表，歡迎大家下載預(yù)覽。下載網(wǎng)址：https://www.sciencedirect.com/journal/journal-of-genetics-and-genomics/vol/48/issue/9本期封面On the Cover: In the natural ecosystem, microorganisms mainly perform their functions and driving roles in the form of microbial communities, which maintain the structure, function and dynamic balance of the ecosystem at all levels. Microbiome research has become the high ground of global scientific and technological competition in human disease prevention and treatment, industrial and agricultural production, and environmental management, etc. With recent progress of microbiome studies, we have an initial knowledge of the composition of microbial communities in various ecosystems, but we are still far from a comprehensive understanding of their community dynamics and functions. The studies in this special issue will unveil microbial composition in diverse hosts and advance our knowledge of the relationship between the microbiome and host’s health, lifestyle, and physiology. The cover image illustrates the host-associated microbial communities directly impact our life everywhere.Mini-ReviewMicrobiota-gut-brain axis in autism spectrum disorderYou Yu, Fangqing Zhaohttps://doi.org/10.1016/j.jgg.2021.07.001中國科學(xué)院北京生命科學(xué)研究院趙方慶研究員團(tuán)隊發(fā)表綜述，從神經(jīng)、免疫及代謝等方面介紹了腸道菌群在自閉癥譜系障礙中調(diào)節(jié)神經(jīng)發(fā)育的最新進(jìn)展。Innate lymphoid cells and gastrointestinal diseaseZiyu Wang, Jun Wanghttps://doi.org/10.1016/j.jgg.2021.08.004中國科學(xué)院微生物研究所王軍研究員團(tuán)隊發(fā)表綜述，總結(jié)了固有淋巴細(xì)胞與多種胃腸道疾病間的關(guān)聯(lián)，展望了固有淋巴細(xì)胞在免疫治療方面可能的應(yīng)用前景。Original ResearchAltered gut microbiome in FUT2 loss-of-function mutants in support of personalized medicine for inflammatory bowel diseasesSijing Cheng, Jun Hu, Xianrui Wu, Ji-an Pan, Na Jiao, Yichen Li,Yibo Huang, Xutao Lin, Yifeng Zou, Yuan Chen, Lixin Zhu, Min Zhi, Ping Lanhttps://doi.org/10.1016/j.jgg.2021.08.003中山大學(xué)附屬第六醫(yī)院胃腸病學(xué)研究所蘭平教授團(tuán)隊和郅敏主任團(tuán)隊合作發(fā)表研究論文，報道了FUT2功能缺失突變可改變腸道菌群，進(jìn)而引發(fā)炎癥性腸病，同時對其相關(guān)機制進(jìn)行探討。Characteristic dysbiosis in gout and the impact of a uric acid-lowering treatment, febuxostat on the gut microbiotaSuxian Lin, Tao Zhang, Lingxiao Zhu, Kun Pang, Saisai Lu, Xin Liao, Senhong Ying, Lixia Zhu, Xin Xu, Jinyu Wu, Xiaobing Wanghttps://doi.org/10.1016/j.jgg.2021.06.009溫州醫(yī)科大學(xué)附屬第一醫(yī)院王曉冰副主任醫(yī)師團(tuán)隊發(fā)表研究論文，報道了降尿酸的非布司他類藥物治療痛風(fēng)前后腸道微生態(tài)變化，確定相應(yīng)微生物區(qū)系功能特征，為揭示痛風(fēng)發(fā)病機制和治療方案提供新思路。Gut microbiota,inflammation, and molecular signatures of host response to infectionWanglong Gou,Yuanqing Fu, Liang Yue, Geng-Dong Chen, Xue Cai, Menglei Shuai, Fengzhe Xu, Xiao Yi, Hao Chen, Yi Zhu, Mian-Li Xiao, Zengliang Jiang, Zelei Miao, Congmei Xiao, Bo Shen, Xiaomai Wu, Haihong Zhao, Wenhua Ling, Jun Wang, Yu-Ming Chen,Tiannan Guo, Ju-Sheng Zhenghttps://doi.org/10.1016/j.jgg.2021.04.002西湖大學(xué)鄭鉅圣教授團(tuán)隊、郭天南教授團(tuán)隊，中山大學(xué)陳裕明教授團(tuán)隊和中國科學(xué)院微生物研究所王軍研究員團(tuán)隊合作發(fā)表研究論文，通過結(jié)合多維組學(xué)生物信息學(xué)分析，探索了腸道菌群、炎癥因子以及COVID-19重癥標(biāo)記物間的關(guān)聯(lián)，為研究腸道菌群與宿主免疫之間的相互作用，評估感染COVID-19后的重癥風(fēng)險提供新線索。Progressive deterioration of the upper respiratory tract and the gut microbiomes in children during the early infection stages of COVID-19Rong Xu, Pengcheng Liu, Tao Zhang, Qunfu Wu, Mei Zeng,Yingying Ma, Xia Jin, Jin Xu, Zhigang Zhang, Chiyu Zhanghttps://doi.org/10.1016/j.jgg.2021.05.004復(fù)旦大學(xué)附屬上海市公共衛(wèi)生臨床中心張馳宇教授團(tuán)隊、云南大學(xué)張志剛研究員團(tuán)隊和復(fù)旦大學(xué)附屬兒科醫(yī)院徐錦研究員團(tuán)隊合作發(fā)表研究論文，報道了COVID-19感染可以引起兒童上呼吸道和腸道菌群的持續(xù)擾動和失衡。Carrageenan oligosaccharides and associated carrageenan-degrading bacteria induce intestinal inflammation in germ-free miceYeshi Yin, Miaomiao Li, Weizhong Gu, Benhua Zeng, Wei Liu,Liying Zhu, XiongePi, Donald A. Primerano, Hongwei D. Yu, Hong Wei, Guangli Yu, Xin Wanghttps://doi.org/10.1016/j.jgg.2021.08.001浙江省農(nóng)科院省部共建農(nóng)產(chǎn)品質(zhì)量安全危害因子與風(fēng)險防控國家重點實驗室王欣研究員團(tuán)隊、中國海洋大學(xué)于廣利教授團(tuán)隊和中國人民解放軍陸軍軍醫(yī)大學(xué)魏泓教授團(tuán)隊合作發(fā)表研究論文，報道了腸道分離獲得的卡拉膠降解菌可以加重誘發(fā)直腸炎癥。Comparative study of gut microbiota from captive and confiscated-rescued wild pangolinsChunbing Liu, Jingyang Hu, Yajiang Wu, David M. Irwin, Wu Chen,Zhigang Zhang, Li Yuhttps://doi.org/10.1016/j.jgg.2021.07.009云南大學(xué)省部共建云南生物資源保護(hù)與利用國家重點實驗室于黎研究員團(tuán)隊、張志剛研究員團(tuán)隊和廣州動物園（廣州野生動物研究中心）陳武高級獸醫(yī)師團(tuán)隊合作發(fā)表研究論文，比較了穿山甲腸道微生物在人工圈養(yǎng)和野生環(huán)境下的微生物組成與功能變化。該研究為優(yōu)化圈養(yǎng)穿山甲的飲食結(jié)構(gòu)、抗生素使用，探討潛在患病機制提供重要理論依據(jù)，對野生穿山甲的保護(hù)具有重要指導(dǎo)意義。The rice histone methylation regulates hub species of the root microbiotaZhiyao Lv, Rui Dai, Haoran Xu, Yongxin Liu, Bo Bai, Ying Meng,Haiyan Li, Xiaofeng Cao, Yang Bai, Xianwei Song, Jingying Zhanghttps://doi.org/10.1016/j.jgg.2021.06.005中國科學(xué)院遺傳與發(fā)育生物學(xué)研究所白洋研究員團(tuán)隊和曹曉風(fēng)研究員團(tuán)隊合作發(fā)表研究論文，報道了組蛋白甲基化修飾對水稻根系微生物群落組裝及核心菌群的調(diào)控作用，為植物表觀遺傳調(diào)控與根系微生物群之間的聯(lián)系提供新思路。ResourceTaxonKit: A practical and efficient NCBI taxonomy toolkitWei Shen, Hong Renhttps://doi.org/10.1016/j.jgg.2021.03.006重慶醫(yī)科大學(xué)病毒性肝炎研究所任紅教授和沈偉博士合作發(fā)表研究論文，報道了一款功能豐富且計算性能高效的NCBI分類學(xué)數(shù)據(jù)操作工具TaxonKit。該工具由7個子命令組成，支持多操作系統(tǒng)，功能相對獨立，且組合后可實現(xiàn)復(fù)雜功能，同時易于集成到生物信息分析流程中。MethodA powerful adaptive microbiome-based association test for microbial association signals with diverse sparsity levelsHan Sun, Xiaoyun Huang, Lingling Fu, Ban Huo, Tingting He, Xingpeng Jianghttps://doi.org/10.1016/j.jgg.2021.08.002華中師范大學(xué)計算機學(xué)院蔣興鵬教授團(tuán)隊發(fā)表研究論文，針對不同稀疏水平的微生物關(guān)聯(lián)信號，提出一種微生物組關(guān)聯(lián)檢驗新方法，用于檢驗微生物組與疾病表型之間關(guān)聯(lián)的統(tǒng)計顯著性。Letter to the EditorAn efficient metatranscriptomic approach for capturing RNA virome and its application to SARS-CoV-2Yao Meng, Liwen Xiao, Wenbing Chen, Fangqing Zhao, Xiang Zhaohttps://doi.org/10.1016/j.jgg.2021.08.005中國科學(xué)院北京生命科學(xué)研究院趙方慶研究員團(tuán)隊和西安交通大學(xué)趙翔助理研究員團(tuán)隊合作發(fā)表研究論文。該研究開發(fā)了一種快速、價廉，對RNA病毒更敏感的宏轉(zhuǎn)錄組測序建庫方法，適用于臨床上對SARS-CoV-2共感染的研究，可用于幫助發(fā)現(xiàn)和鑒定未知病原。EVenn: Easy to create repeatable and editable Venn diagrams and Venn networks onlineTong Chen, Haiyan Zhang, Yu Liu, Yong-Xin Liu, Luqi Huanghttps://doi.org/10.1016/j.jgg.2021.07.007中國中醫(yī)科學(xué)院黃璐琦院士團(tuán)隊和中國科學(xué)院遺傳與發(fā)育生物學(xué)研究所劉永鑫高級工程師合作發(fā)表研究論文，介紹了一款用于數(shù)據(jù)交互性探索和可視化的一站式Venn圖和Venn網(wǎng)絡(luò)在線繪制平臺。